Influence of osteoporosis and mechanical loading on bone around osseointegrated dental implants: A rodent study
نویسندگان
چکیده
This study aimed to evaluate the influence of estrogen deficiency and mechanical loading on bone around osseointegrated dental implants in a rat jaw model. The maxillary right first molars 36 rats were extracted. One week later, divided into an unloaded group loaded group; short head long inserted respectively. Nine weeks after implantation, further subjected ovariectomy (OVX) or sham surgery. All animals euthanized 21 OVX. Micro-computed tomography, histological histomorphometrical evaluation undertaken. Systemic mineral density volume fraction decreased OVX groups compared with controls. Histomorphometrical observation indicated that showed significantly damaged osseointegration loss versus group. Both (BD) inside peri-implant grooves percentage bone-to-implant contact (BIC) lower than sham-surgery groups, although increased BIC BD An number positive cells for tartrate-resistant acid phosphatase was observed sclerostin-positive osteocytes under conditions both In conclusion, could be risk factor long-term stability implants, while attenuate negative formation osseointegration.
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ژورنال
عنوان ژورنال: Journal of The Mechanical Behavior of Biomedical Materials
سال: 2021
ISSN: ['1751-6161', '1878-0180']
DOI: https://doi.org/10.1016/j.jmbbm.2021.104771